Dataset Information

Resistome diversity in cattle and the environment decreases during beef production.

ABSTRACT: Antimicrobial resistant determinants (ARDs) can be transmitted from livestock systems through meat products or environmental effluents. The public health risk posed by these two routes is not well understood, particularly in non-pathogenic bacteria. We collected pooled samples from 8 groups of 1741 commercial cattle as they moved through the process of beef production from feedlot entry through slaughter. We recorded antimicrobial drug exposures and interrogated the resistome at points in production when management procedures could potentially influence ARD abundance and/or transmission. Over 300 unique ARDs were identified. Resistome diversity decreased while cattle were in the feedlot, indicating selective pressure. ARDs were not identified in beef products, suggesting that slaughter interventions may reduce the risk of transmission of ARDs to beef consumers. This report highlights the utility and limitations of metagenomics for assessing public health risks regarding antimicrobial resistance, and demonstrates that environmental pathways may represent a greater risk than the food supply.

SUBMITTER: Noyes NR

PROVIDER: S-EPMC4798965 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Resistome diversity in cattle and the environment decreases during beef production.

Noyes Noelle R NR Yang Xiang X Linke Lyndsey M LM Magnuson Roberta J RJ Dettenwanger Adam A Cook Shaun S Geornaras Ifigenia I Woerner Dale E DE Gow Sheryl P SP McAllister Tim A TA Yang Hua H Ruiz Jaime J Jones Kenneth L KL Boucher Christina A CA Morley Paul S PS Belk Keith E KE

eLife 20160308

Antimicrobial resistant determinants (ARDs) can be transmitted from livestock systems through meat products or environmental effluents. The public health risk posed by these two routes is not well understood, particularly in non-pathogenic bacteria. We collected pooled samples from 8 groups of 1741 commercial cattle as they moved through the process of beef production from feedlot entry through slaughter. We recorded antimicrobial drug exposures and interrogated the resistome at points in produc ...[more]

PMID: 26952213

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Dataset Information

Resistome diversity in cattle and the environment decreases during beef production.

Publications

Resistome diversity in cattle and the environment decreases during beef production.

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