Ontology highlight
ABSTRACT:
SUBMITTER: Wymeersch FJ
PROVIDER: S-EPMC4798969 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Wymeersch Filip J FJ Huang Yali Y Blin Guillaume G Cambray Noemí N Wilkie Ron R Wong Frederick C K FC Wilson Valerie V
eLife 20160118
The rostrocaudal (head-to-tail) axis is supplied by populations of progenitors at the caudal end of the embryo. Despite recent advances characterising one of these populations, the neuromesodermal progenitors, their nature and relationship to other populations remains unclear. Here we show that neuromesodermal progenitors are a single Sox2(low)T(low) entity whose choice of neural or mesodermal fate is dictated by their position in the progenitor region. The choice of mesoderm fate is Wnt/β-caten ...[more]