Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura T
PROVIDER: S-EPMC4799364 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Nakamura Tsutomu T Arima-Yoshida Fumiko F Sakaue Fumika F Nasu-Nishimura Yukiko Y Takeda Yasuko Y Matsuura Ken K Akshoomoff Natacha N Mattson Sarah N SN Grossfeld Paul D PD Manabe Toshiya T Akiyama Tetsu T
Nature communications 20160316
Jacobsen syndrome (JBS) is a rare congenital disorder caused by a terminal deletion of the long arm of chromosome 11. A subset of patients exhibit social behavioural problems that meet the diagnostic criteria for autism spectrum disorder (ASD); however, the underlying molecular pathogenesis remains poorly understood. PX-RICS is located in the chromosomal region commonly deleted in JBS patients with autistic-like behaviour. Here we report that PX-RICS-deficient mice exhibit ASD-like social behavi ...[more]