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Isoflavones and Prostate Cancer: A Review of Some Critical Issues.

ABSTRACT: The purpose of this review is to discuss some critical issues of isoflavones protective against the development of prostate cancer (PCa).Data cited in this review were obtained primarily from PubMed and Embase from 1975 to 2015.Articles were selected with the search terms "isoflavone", "Phytoestrogen", "soy", "genistin", and "PCa ".Isoflavones do not play an important role on prostate-specific antigen levels reduction in PCa patients or healthy men. The effect of isoflavones on sex hormone levels and PCa risk may be determined by equol converting bacteria in the intestine, specific polymorphic variation and concentrations of isoflavones. The intake of various types of phytoestrogens with lower concentrations in the daily diet may produce synergistic effects against PCa. Moreover, prostate tissue may concentrate isoflavones to potentially anti-carcinogenic levels. In addition, it is noteworthy that isoflavones may act as an agonist in PCa.Isoflavones play a protective role against the development of PCa. However, careful consideration should be given when isoflavones are used in the prevention and treatment of PCa.

SUBMITTER: Zhang HY

PROVIDER: S-EPMC4799580 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Isoflavones and Prostate Cancer: A Review of Some Critical Issues.

Zhang Hong-Yi HY Cui Jie J Zhang Ye Y Wang Zhen-Long ZL Chong Tie T Wang Zi-Ming ZM

Chinese medical journal 20160201 3

<h4>Objective</h4>The purpose of this review is to discuss some critical issues of isoflavones protective against the development of prostate cancer (PCa).<h4>Data sources</h4>Data cited in this review were obtained primarily from PubMed and Embase from 1975 to 2015.<h4>Study selection</h4>Articles were selected with the search terms "isoflavone", "Phytoestrogen", "soy", "genistin", and "PCa ".<h4>Results</h4>Isoflavones do not play an important role on prostate-specific antigen levels reduction ...[more]

PMID: 26831238

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Project description:BackgroundGenomic research on neurodevelopmental disorders (NDDs), particularly involving minors, combines and amplifies existing research ethics issues for biomedical research. We performed a review of the literature on the ethical issues associated with genomic research involving children affected by NDDs as an aid to researchers to better anticipate and address ethical concerns.ResultsQualitative thematic analysis of the included articles revealed themes in three main areas: research design and ethics review, inclusion of research participants, and communication of research results. Ethical issues known to be associated with genomic research in general, such as privacy risks and informed consent/assent, seem especially pressing for NDD participants because of their potentially decreased cognitive abilities, increased vulnerability, and stigma associated with mental health problems. Additionally, there are informational risks: learning genetic information about NDD may have psychological and social impact, not only for the research participant but also for family members. However, there are potential benefits associated with research participation, too: by enrolling in research, the participants may access genetic testing and thus increase their chances of receiving a (genetic) diagnosis for their neurodevelopmental symptoms, prognostic or predictive information about disease progression or the risk of concurrent future disorders. Based on the results of our review, we developed an ethics checklist for genomic research involving children affected by NDDs.ConclusionsIn setting up and designing genomic research efforts in NDD, researchers should partner with communities of persons with NDDs. Particular attention should be paid to preventing disproportional burdens of research participation of children with NDDs and their siblings, parents and other family members. Researchers should carefully tailor the information and informed consent procedures to avoid therapeutic and diagnostic misconception in NDD research. To better anticipate and address ethical issues in specific NDD studies, we suggest researchers to use the ethics checklist for genomic research involving children affected by NDDs presented in this paper.

Dataset Information

Isoflavones and Prostate Cancer: A Review of Some Critical Issues.

Publications

Isoflavones and Prostate Cancer: A Review of Some Critical Issues.

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