HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults.
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SUBMITTER: Matthews PC
PROVIDER: S-EPMC4799671 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults.
Matthews Philippa C PC Carlson Jonathan M JM Beloukas Apostolos A Malik Amna A Jooste Pieter P Ogwu Anthony A Shapiro Roger R Riddell Lynn L Chen Fabian F Luzzi Graz G Jesuthasan Gerald G Jeffery Katie K Jojic Nebojsa N Ndung'u Thumbi T Carrington Mary M Goulder Philip J R PJ Geretti Anna Maria AM Klenerman Paul P
The Journal of infectious diseases 20151209 8
Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are ...[more]
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