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NEURONAL MODELING. Single-trial spike trains in parietal cortex reveal discrete steps during decision-making.

ABSTRACT: Neurons in the macaque lateral intraparietal (LIP) area exhibit firing rates that appear to ramp upward or downward during decision-making. These ramps are commonly assumed to reflect the gradual accumulation of evidence toward a decision threshold. However, the ramping in trial-averaged responses could instead arise from instantaneous jumps at different times on different trials. We examined single-trial responses in LIP using statistical methods for fitting and comparing latent dynamical spike-train models. We compared models with latent spike rates governed by either continuous diffusion-to-bound dynamics or discrete "stepping" dynamics. Roughly three-quarters of the choice-selective neurons we recorded were better described by the stepping model. Moreover, the inferred steps carried more information about the animal's choice than spike counts.

SUBMITTER: Latimer KW

PROVIDER: S-EPMC4799998 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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NEURONAL MODELING. Single-trial spike trains in parietal cortex reveal discrete steps during decision-making.

Latimer Kenneth W KW Yates Jacob L JL Meister Miriam L R ML Huk Alexander C AC Pillow Jonathan W JW

Science (New York, N.Y.) 20150701 6244

Neurons in the macaque lateral intraparietal (LIP) area exhibit firing rates that appear to ramp upward or downward during decision-making. These ramps are commonly assumed to reflect the gradual accumulation of evidence toward a decision threshold. However, the ramping in trial-averaged responses could instead arise from instantaneous jumps at different times on different trials. We examined single-trial responses in LIP using statistical methods for fitting and comparing latent dynamical spike ...[more]

PMID: 26160947

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