Ontology highlight
ABSTRACT:
SUBMITTER: Ceccacci E
PROVIDER: S-EPMC4800301 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Ceccacci Elena E Minucci Saverio S
British journal of cancer 20160223 6
Histone deacetylases (HDACs) are a key component of the epigenetic machinery regulating gene expression, and behave as oncogenes in several cancer types, spurring the development of HDAC inhibitors (HDACi) as anticancer drugs. This review discusses new results regarding the role of HDACs in cancer and the effect of HDACi on tumour cells, focusing on haematological malignancies, particularly acute myeloid leukaemia. Histone deacetylases may have opposite roles at different stages of tumour progre ...[more]