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Efficient Red Light Photo-Uncaging of Active Molecules in Water Upon Assembly into Nanoparticles.

ABSTRACT: We introduce a means of efficiently photo-uncaging active compounds from amino-1,4-benzoquinone in aqueous environments. Aqueous photochemistry of this photocage with one-photon red light is typically not efficient unless the photocaged molecules are allowed to assemble into nanoparticles. A variety of biologically active molecules were functionalized with the photocage and subsequently formulated into water-dispersible nanoparticles. Red light irradiation through various mammalian tissues achieved efficient photo-uncaging. Co-encapsulation of NIR fluorescent dyes and subsequent photomodulation provides a NIR fluorescent tool to assess both particle location and successful photorelease.

SUBMITTER: Carling CJ

PROVIDER: S-EPMC4800316 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Efficient Red Light Photo-Uncaging of Active Molecules in Water Upon Assembly into Nanoparticles.

Carling Carl-Johan CJ Olejniczak Jason J Foucault-Collet Alexandra A Collet Guillaume G Viger Mathieu L ML Huu Viet Anh Nguyen VA Duggan Brendan M BM Almutairi Adah A

Chemical science 20151223 3

We introduce a means of efficiently photo-uncaging active compounds from amino-1,4-benzoquinone in aqueous environments. Aqueous photochemistry of this photocage with one-photon red light is typically not efficient unless the photocaged molecules are allowed to assemble into nanoparticles. A variety of biologically active molecules were functionalized with the photocage and subsequently formulated into water-dispersible nanoparticles. Red light irradiation through various mammalian tissues achie ...[more]

PMID: 27014436

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