Efficient Red Light Photo-Uncaging of Active Molecules in Water Upon Assembly into Nanoparticles.
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ABSTRACT: We introduce a means of efficiently photo-uncaging active compounds from amino-1,4-benzoquinone in aqueous environments. Aqueous photochemistry of this photocage with one-photon red light is typically not efficient unless the photocaged molecules are allowed to assemble into nanoparticles. A variety of biologically active molecules were functionalized with the photocage and subsequently formulated into water-dispersible nanoparticles. Red light irradiation through various mammalian tissues achieved efficient photo-uncaging. Co-encapsulation of NIR fluorescent dyes and subsequent photomodulation provides a NIR fluorescent tool to assess both particle location and successful photorelease.
SUBMITTER: Carling CJ
PROVIDER: S-EPMC4800316 | biostudies-literature |
REPOSITORIES: biostudies-literature
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