Ontology highlight
ABSTRACT:
SUBMITTER: Kim MY
PROVIDER: S-EPMC4800405 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Kim Mee Young MY Hwang Do Won DW Li Fangyuan F Choi Yoori Y Byun Jung Woo JW Kim Dongho D Kim Jee-Eun JE Char Kookheon K Lee Dong Soo DS
Scientific reports 20160321
Detection of cellular expression of long noncoding RNAs (lncRNAs) was elusive due to the ambiguity of exposure of their reactive sequences associated with their secondary/tertiary structures and dynamic binding of proteins around lncRNAs. Herein, we developed graphene-based detection techniques exploiting the quenching capability of graphene oxide (GO) flakes for fluorescent dye (FAM)-labeled single-stranded siRNAs and consequent un-quenching by their detachment from GO by matching lncRNAs. A br ...[more]