Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.
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ABSTRACT:
SUBMITTER: Galloway-Pena J
PROVIDER: S-EPMC4800461 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.
Galloway-Peña Jessica J Clement Meredith E ME Sharma Kuinkel Batu K BK Ruffin Felicia F Flores Anthony R AR Levinson Howard H Shelburne Samuel A SA Moore Zack Z Fowler Vance G VG
Open forum infectious diseases 20160101 1
Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks. ...[more]
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