Ontology highlight
ABSTRACT:
SUBMITTER: de Rooij JD
PROVIDER: S-EPMC4800704 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
de Rooij Jasmijn D E JD Beuling Eva E van den Heuvel-Eibrink Marry M MM Obulkasim Askar A Baruchel André A Trka Jan J Reinhardt Dirk D Sonneveld Edwin E Gibson Brenda E S BE Pieters Rob R Zimmermann Martin M Zwaan C Michel CM Fornerod Maarten M
Haematologica 20150611 9
IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia. Recent studies suggest that IKZF1 is also involved in myeloid differentiation. To investigate whether IKZF1 deletions also play a role in pediatric acute myeloid leukemia, we screened a panel of pediatric acute myeloid leukemia samples for deletions of the IKZF1 locus using multiplex ligation-dependent probe amplification and for mutations us ...[more]