Identification of motions in membrane proteins by elastic network models and their experimental validation.

ABSTRACT: Identifying the functional motions of membrane proteins is difficult because they range from large-scale collective dynamics to local small atomic fluctuations at different timescales that are difficult to measure experimentally due to the hydrophobic nature of these proteins. Elastic Network Models, and in particular their most widely used implementation, the Anisotropic Network Model (ANM), have proven to be useful computational methods in many recent applications to predict membrane protein dynamics. These models are based on the premise that biomolecules possess intrinsic mechanical characteristics uniquely defined by their particular architectures. In the ANM, interactions between residues in close proximity are represented by harmonic potentials with a uniform spring constant. The sl

SUBMITTER: Isin B 

PROVIDER: S-EPMC4801040 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature