Sterol hindrance of Orai activation.
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ABSTRACT:
SUBMITTER: Hooper R
PROVIDER: S-EPMC4801107 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Sterol hindrance of Orai activation.
Hooper Robert R Rothberg Brad S BS Soboloff Jonathan J
Science signaling 20160308 418
Orai channels at the plasma membrane mediate store-operated Ca(2+) entry in response to Ca(2+) depletion of the endoplasmic reticulum. Orai channels are gated by stromal-interacting molecule proteins, which act as Ca(2+) sensors, and the association of these proteins is enhanced in cholesterol-rich lipid rafts. In research published in Science Signaling, Derler et al. report that cholesterol inhibits Orai function through direct association with the channel amino terminus. ...[more]
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