Ontology highlight
ABSTRACT:
SUBMITTER: Baiocchini A
PROVIDER: S-EPMC4801190 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Baiocchini Andrea A Montaldo Claudia C Conigliaro Alice A Grimaldi Alessio A Correani Virginia V Mura Francesco F Ciccosanti Fabiola F Rotiroti Nicolina N Brenna Alessia A Montalbano Marzia M D'Offizi Gianpiero G Capobianchi Maria Rosaria MR Alessandro Riccardo R Piacentini Mauro M Schininà Maria Eugenia ME Maras Bruno B Del Nonno Franca F Tripodi Marco M Mancone Carmine C
PloS one 20160321 3
Chronic liver damage leads to pathological accumulation of ECM proteins (liver fibrosis). Comprehensive characterization of the human ECM molecular composition is essential for gaining insights into the mechanisms of liver disease. To date, studies of ECM remodeling in human liver diseases have been hampered by the unavailability of purified ECM. Here, we developed a decellularization method to purify ECM scaffolds from human liver tissues. Histological and electron microscopy analyses demonstra ...[more]