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Enhanced Diabetes Susceptibility in Community Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype.


ABSTRACT: Despite Apolipoprotein E (ApoE) being one of the main apolipoproteins in the blood, the association between its genotype and the high cholesterol or blood glucose levels commonly seen in clinical practice is inconclusive. Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes were assessed and were simultaneously tested for weight, height, blood glucose, triglycerides, cholesterol, and high- and low-density lipoprotein. In addition, gender, age, years of education, cognitive function, and medical history was recorded. Subjects were divided into 3 groups based on APOE genotype: APOE ?2 group (?2/?2 and ?2/?3), APOE ?3 group (?3/?3), and APOE ?4 group (?2/?4, ?3/?4 and ?4/?4). Comparisons between groups were conducted for the incidence of diabetes, high blood pressure, and dementia, as well as for differences in body-mass index, fasting plasma glucose, and blood lipids. The APOE ?3/?3 genotype exhibited the highest frequency (70.4%) among the subjects. Participants in the APOE ?3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ?2 and APOE ?4 groups (P<0.05). The APOE ?3 group had slightly higher abnormal fasting plasma glucose values than did the APOE ?2 group (P = 0.065). Furthermore, the APOE3 genotype was significantly correlated with both fasting plasma glucose level and glucose abnormality (P< 0.05) and trended toward statistically significant correlation with diabetes (P = 0.082). The correlation between APOE2 and low low-density lipoprotein levels also approached statistical significance (P = 0.052). Thus, elderly community dwelling residents of Han ethnicity carrying the APOE ?3/?3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.

SUBMITTER: Ban CX 

PROVIDER: S-EPMC4801405 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Enhanced Diabetes Susceptibility in Community Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype.

Ban Chun-Xia CX   Zhong Li L   Wang Tao T   Zhu Min-Jie MJ   Wang Jing-Hua JH   Zhang Zhen-Lian ZL   Wang Zhe Z   Su Ning N   Liu Yuan-Yuan YY   Shi Yan-Chen YC   Xiao Shi-Fu SF   Li Xia X  

PloS one 20160321 3


Despite Apolipoprotein E (ApoE) being one of the main apolipoproteins in the blood, the association between its genotype and the high cholesterol or blood glucose levels commonly seen in clinical practice is inconclusive. Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes wer  ...[more]

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