High-Resolution Microfluidic Single-Cell Transcriptional Profiling Reveals Clinically Relevant Subtypes among Human Stem Cell Populations Commonly Utilized in Cell-Based Therapies.
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ABSTRACT:
SUBMITTER: Rennert RC
PROVIDER: S-EPMC4801858 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
High-Resolution Microfluidic Single-Cell Transcriptional Profiling Reveals Clinically Relevant Subtypes among Human Stem Cell Populations Commonly Utilized in Cell-Based Therapies.
Rennert Robert C RC Schäfer Richard R Bliss Tonya T Januszyk Michael M Sorkin Michael M Achrol Achal S AS Rodrigues Melanie M Maan Zeshaan N ZN Kluba Torsten T Steinberg Gary K GK Gurtner Geoffrey C GC
Frontiers in neurology 20160322
Stem cell therapies can promote neural repair and regeneration, yet controversy regarding optimal cell source and mechanism of action has slowed clinical translation, potentially due to undefined cellular heterogeneity. Single-cell resolution is needed to identify clinically relevant subpopulations with the highest therapeutic relevance. We combine single-cell microfluidic analysis with advanced computational modeling to study for the first time two common sources for cell-based therapies, human ...[more]
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