Ontology highlight
ABSTRACT:
SUBMITTER: Salzman DW
PROVIDER: S-EPMC4802117 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Salzman David W DW Nakamura Kotoka K Nallur Sunitha S Dookwah Michelle T MT Metheetrairut Chanatip C Slack Frank J FJ Weidhaas Joanne B JB
Nature communications 20160321
MicroRNA (miRNA) expression is tightly regulated by several mechanisms, including transcription and cleavage of the miRNA precursor RNAs, to generate a mature miRNA, which is thought to be directly correlated with activity. MiR-34 is a tumour-suppressor miRNA important in cell survival, that is transcriptionally upregulated by p53 in response to DNA damage. Here, we show for the first time that there is a pool of mature miR-34 in cells that lacks a 5'-phosphate and is inactive. Following exposur ...[more]