Reduction of Tetrathionate by Mammalian Thioredoxin Reductase.
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ABSTRACT:
SUBMITTER: Narayan V
PROVIDER: S-EPMC4802500 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Reduction of Tetrathionate by Mammalian Thioredoxin Reductase.
Narayan Vivek V Kudva Avinash K AK Prabhu K Sandeep KS
Biochemistry 20150813 33
Tetrathionate, a polythionate oxidation product of microbial hydrogen sulfide and reactive oxygen species from immune cells in the gut, serves as a terminal electron acceptor to confer a growth advantage for Salmonella and other enterobacteria. Here we show that the rat liver selenoenzyme thioredoxin reductase (Txnrd1, TR1) efficiently reduces tetrathionate in vitro. Furthermore, lysates of selenium-supplemented murine macrophages also displayed activity toward tetrathionate, while cells lacking ...[more]
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