Ontology highlight
ABSTRACT:
SUBMITTER: Roizen JD
PROVIDER: S-EPMC4803160 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
The Journal of clinical endocrinology and metabolism 20151228 3
<h4>Context</h4>Pseudohypoparathyroidism type 1A (PHP1A) is caused by loss-of-function mutations on the maternally inherited GNAS allele and is associated with early-onset obesity, neurocognitive defects, and resistance to multiple hormones. The role of energy intake vs central regulation of energy expenditure in the pathophysiology of obesity remains unclear.<h4>Objective</h4>The aim of this study was to evaluate resting energy expenditure (REE) in participants with PHP1A.<h4>Design</h4>We asse ...[more]