Ontology highlight
ABSTRACT:
SUBMITTER: Makimura H
PROVIDER: S-EPMC4803166 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Makimura Hideo H Stanley Takara L TL Suresh Caroline C De Sousa-Coelho Ana Luisa AL Frontera Walter R WR Syu Stephanie S Braun Laurie R LR Looby Sara E SE Feldpausch Meghan N MN Torriani Martin M Lee Hang H Patti Mary-Elizabeth ME Grinspoon Steven K SK
The Journal of clinical endocrinology and metabolism 20151221 3
<h4>Context</h4>Increased circulating free fatty acids (FFAs) have been proposed to contribute to insulin resistance in obesity. Short-term studies have investigated the effects of acipimox, an inhibitor of hormone-sensitive lipase, on glucose homeostasis, but longer-term studies have not been performed.<h4>Objective</h4>To test the hypothesis that long-term treatment with acipimox would reduce FFA and improve insulin sensitivity among nondiabetic, insulin-resistant, obese subjects.<h4>Design, s ...[more]