Ontology highlight
ABSTRACT:
SUBMITTER: Stocki P
PROVIDER: S-EPMC4803302 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Stocki Pawel P Sawicki Maxime M Mays Charles E CE Hong Seo Jung SJ Chapman Daniel C DC Westaway David D Williams David B DB
Molecular biology of the cell 20160113 5
Prion diseases are fatal neurodegenerative disorders for which there is no effective treatment. Because the cellular prion protein (PrP(C)) is required for propagation of the infectious scrapie form of the protein, one therapeutic strategy is to reduce PrP(C) expression. Recently FK506, an inhibitor of the FKBP family of peptidyl prolyl isomerases, was shown to increase survival in animal models of prion disease, with proposed mechanisms including calcineurin inhibition, induction of autophagy, ...[more]