Ontology highlight
ABSTRACT:
SUBMITTER: Meng D
PROVIDER: S-EPMC4803309 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20160113 5
NIMA-related kinases (Nrks or Neks) have emerged as key regulators of ciliogenesis. In human, mutations in Nek1 and Nek8 cause cilia-related disorders. The ciliary functions of Nrks are mostly revealed by genetic studies; however, the underlying mechanisms are not well understood. Here we show that a Chlamydomonas Nrk, CNK4, regulates ciliary stability and length. CNK4 is localized to the basal body region and the flagella. The cnk4-null mutant exhibited long flagella, with formation of flagella ...[more]