Noise Expands the Response Range of the Bacillus subtilis Competence Circuit.
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ABSTRACT:
SUBMITTER: Mugler A
PROVIDER: S-EPMC4803322 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
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Noise Expands the Response Range of the Bacillus subtilis Competence Circuit.
Mugler Andrew A Kittisopikul Mark M Hayden Luke L Liu Jintao J Wiggins Chris H CH Süel Gürol M GM Walczak Aleksandra M AM
PLoS computational biology 20160322 3
Gene regulatory circuits must contend with intrinsic noise that arises due to finite numbers of proteins. While some circuits act to reduce this noise, others appear to exploit it. A striking example is the competence circuit in Bacillus subtilis, which exhibits much larger noise in the duration of its competence events than a synthetically constructed analog that performs the same function. Here, using stochastic modeling and fluorescence microscopy, we show that this larger noise allows cells ...[more]
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