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Biomaterials-based strategies for salivary gland tissue regeneration.

ABSTRACT: The salivary gland is a complex, secretory tissue that produces saliva and maintains oral homeostasis. Radiation induced salivary gland atrophy, manifested as "dry mouth" or xerostomia, poses a significant clinical challenge. Tissue engineering recently has emerged as an alternative, long-term treatment strategy for xerostomia. In this review, we summarize recent efforts towards the development of functional and implantable salivary glands utilizing designed polymeric substrates or synthetic matrices/scaffolds. Although the in vitro engineering of a complex implantable salivary gland is technically challenging, opportunities exist for multidisciplinary teams to assemble implantable and secretory tissue modules by combining stem/progenitor cells found in the adult glands with biomimetic and cell-instructive materials.

SUBMITTER: Ozdemir T

PROVIDER: S-EPMC4803517 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Biomaterials-based strategies for salivary gland tissue regeneration.

Ozdemir Tugba T Fowler Eric W EW Hao Ying Y Ravikrishnan Anitha A Harrington Daniel A DA Witt Robert L RL Farach-Carson Mary C MC Pradhan-Bhatt Swati S Jia Xinqiao X

Biomaterials science 20160215 4

The salivary gland is a complex, secretory tissue that produces saliva and maintains oral homeostasis. Radiation induced salivary gland atrophy, manifested as "dry mouth" or xerostomia, poses a significant clinical challenge. Tissue engineering recently has emerged as an alternative, long-term treatment strategy for xerostomia. In this review, we summarize recent efforts towards the development of functional and implantable salivary glands utilizing designed polymeric substrates or synthetic mat ...[more]

PMID: 26878077

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