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Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity.

ABSTRACT: Major depression is a chronic and debilitating illness that effects approximately 1 in 5 people, but currently available treatments are limited by low rates of efficacy, therapeutic time lag, and undesirable side effects. Recent efforts have been directed towards investigating rapid-acting agents that reverse the behavioral and neuronal deficits of chronic stress and depression, notably the glutamate NMDA receptor antagonist ketamine. The cellular mechanisms underlying the rapid antidepressant actions of ketamine and related agents are discussed, as well as novel, selective glutamatergic receptor targets that are safer and have fewer side effects.

SUBMITTER: Gerhard DM

PROVIDER: S-EPMC4803609 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity.

Gerhard Danielle M DM Wohleb Eric S ES Duman Ronald S RS

Drug discovery today 20160206 3

Major depression is a chronic and debilitating illness that effects approximately 1 in 5 people, but currently available treatments are limited by low rates of efficacy, therapeutic time lag, and undesirable side effects. Recent efforts have been directed towards investigating rapid-acting agents that reverse the behavioral and neuronal deficits of chronic stress and depression, notably the glutamate NMDA receptor antagonist ketamine. The cellular mechanisms underlying the rapid antidepressant a ...[more]

PMID: 26854424

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