Ontology highlight
ABSTRACT:
SUBMITTER: Glastras SJ
PROVIDER: S-EPMC4804207 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Glastras Sarah J SJ Chen Hui H McGrath Rachel T RT Zaky Amgad A AA Gill Anthony J AJ Pollock Carol A CA Saad Sonia S
Scientific reports 20160323
Maternal obesity is associated with an increased risk of chronic disease in offspring, including type 2 diabetes (T2D). Exendin-4 (Exd-4) activates the glucagon like peptide-1 (GLP-1) receptor thereby decreasing serum glucose levels and body weight. In addition, Exd-4 has been shown to reduce renal and cardiac complications in experimental models of T2D. We hypothesized that treatment with Exd-4 would ameliorate the detrimental effects of maternal and diet-induced obesity on renal characteristic ...[more]