Ontology highlight
ABSTRACT:
SUBMITTER: Finkel TH
PROVIDER: S-EPMC4804485 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Finkel Terri H TH Li Jin J Wei Zhi Z Wang Wei W Zhang Haitao H Behrens Edward M EM Reuschel Emma L EL Limou Sophie S Wise Carol C Punaro Marilynn M Becker Mara L ML Munro Jane E JE Flatø Berit B Førre Øystein Ø Thompson Susan D SD Langefeld Carl D CD Glass David N DN Glessner Joseph T JT Kim Cecilia E CE Frackelton Edward E Shivers Debra K DK Thomas Kelly A KA Chiavacci Rosetta M RM Hou Cuiping C Xu Kexiang K Snyder James J Qiu Haijun H Mentch Frank F Wang Kai K Winkler Cheryl A CA Lie Benedicte A BA Ellis Justine A JA Hakonarson Hakon H
BMC medical genetics 20160322
<h4>Background</h4>Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease among children, the etiology of which involves a strong genetic component, but much of the underlying genetic determinants still remain unknown. Our aim was to identify novel genetic variants that predispose to JIA.<h4>Methods</h4>We performed a genome-wide association study (GWAS) and replication in a total of 1166 JIA cases and 9500 unrelated controls of European ancestry. Correlation of SNP gen ...[more]