Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi K
PROVIDER: S-EPMC4804759 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Takahashi Koichi K Kantarjian Hagop H Garcia-Manero Guillermo G Borthakur Gautam G Kadia Tapan T DiNardo Courtney C Jabbour Elias E Pierce Sherry S Estrov Zeev Z Konopleva Marina M Andreeff Michael M Ravandi Farhad F Cortes Jorge J
Clinical lymphoma, myeloma & leukemia 20151124 3
<h4>Introduction</h4>Most patients with acute myeloid leukemia (AML) age ≥ 60 years are not offered intensive induction because of high mortality. Phase 2 studies of clofarabine plus low-dose cytarabine (CLDA) as frontline therapy for elderly AML patients demonstrated high response and acceptable toxicity.<h4>Patients and methods</h4>We hypothesized that induction therapy with CLDA provides equivalent outcomes to but is less toxic than intensive induction in these patients. To test this hypothes ...[more]