RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4805198 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2.
Wang Xiaoming X Zhou Minran M Fu Yue Y Sun Ting T Chen Jin J Qin Xuemei X Yu Yuan Y Jia Jihui J Chen Chunyan C
PloS one 20160323 3
Despite recent increases in the cure rate of acute lymphoblastic leukemia (ALL), adult ALL remains a high-risk disease that exhibits a high relapse rate. In this study, we found that the histone demethylase retinoblastoma binding protein-2 (RBP2) was overexpressed in both on-going and relapse cases of adult ALL, which revealed that RBP2 overexpression was not only involved in the pathogenesis of ALL but that its overexpression might also be related to relapse of the disease. RBP2 knockdown induc ...[more]
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