Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC4805274 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Sun Lili L Tabaka Marcin M Hou Sen S Li Lin L Burdzy Krzysztof K Aksimentiev Aleksei A Maffeo Christopher C Zhang Xuzhu X Holyst Robert R
PloS one 20160323 3
LacI is commonly used as a model to study the protein-DNA interaction and gene regulation. The headpiece of the lac-repressor (LacI) protein is an ideal system for investigation of nonspecific binding of the whole LacI protein to DNA. The hinge region of the headpiece has been known to play a key role in the specific binding of LacI to DNA, whereas its role in nonspecific binding process has not been elucidated. Here, we report the results of explicit solvent molecular dynamics simulation and co ...[more]