Ontology highlight
ABSTRACT:
SUBMITTER: Kitange GJ
PROVIDER: S-EPMC4805508 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Kitange Gaspar J GJ Mladek Ann C AC Schroeder Mark A MA Pokorny Jenny C JC Carlson Brett L BL Zhang Yuji Y Nair Asha A AA Lee Jeong-Heon JH Yan Huihuang H Decker Paul A PA Zhang Zhiguo Z Sarkaria Jann N JN
Cell reports 20160310 11
Here we provide evidence that RBBP4 modulates temozolomide (TMZ) sensitivity through coordinate regulation of two key DNA repair genes critical for recovery from TMZ-induced DNA damage: methylguanine-DNA-methyltransferase (MGMT) and RAD51. Disruption of RBBP4 enhanced TMZ sensitivity, induced synthetic lethality to PARP inhibition, and increased DNA damage signaling in response to TMZ. Moreover, RBBP4 silencing enhanced TMZ-induced H2AX phosphorylation and apoptosis in GBM cells. Intriguingly, R ...[more]