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Classic Analysis of Biopolymer Dynamics Is Model Free.

ABSTRACT: Early analysis of biopolymer dynamics relied on a variety of motional models that were difficult to distinguish and sometimes gave contradictory results. The Lipari-Szabo model-free approach (documented in a 1980 article in Biophysical Journal, as well as in two more comprehensive 1982 articles in the Journal of the American Chemical Society, provided a simple formalism that allowed investigators to understand fluorescence and NMR experimental data without having to specify a motional model. Although the model-free method is not universally applicable (for example, its assumption of a uniform correlation time for overall molecular tumbling can be problematic for biomolecules containing areas of disorder), it remains the most popular and widely used technique for analyzing molecular motion.

SUBMITTER: Fenwick RB

PROVIDER: S-EPMC4805862 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Classic Analysis of Biopolymer Dynamics Is Model Free.

Fenwick R Bryn RB Dyson H Jane HJ

Biophysical journal 20160101 1

Early analysis of biopolymer dynamics relied on a variety of motional models that were difficult to distinguish and sometimes gave contradictory results. The Lipari-Szabo model-free approach (documented in a 1980 article in Biophysical Journal, as well as in two more comprehensive 1982 articles in the Journal of the American Chemical Society, provided a simple formalism that allowed investigators to understand fluorescence and NMR experimental data without having to specify a motional model. Alt ...[more]

PMID: 26745403

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