Shock Wave-Induced Damage of a Protein by Void Collapse.
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ABSTRACT:
SUBMITTER: Lau EY
PROVIDER: S-EPMC4806186 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Shock Wave-Induced Damage of a Protein by Void Collapse.
Lau Edmond Y EY Berkowitz Max L ML Schwegler Eric E
Biophysical journal 20160101 1
In this study, we report on a series of molecular dynamics simulations that were used to examine the effects of shock waves on a membrane-bound ion channel. A planar shock wave was found to compress the ion channel upon impact, but the protein geometry resembles the crystal structure as soon as the solvent density begins to dissipate. When a void was placed in close proximity to the membrane, the shock wave proved to be more destructive to the protein due to formation of a nanojet that results f ...[more]
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