Ontology highlight
ABSTRACT:
SUBMITTER: Jacobson I
PROVIDER: S-EPMC4806200 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Jacobson Ira I Zeuzem Stefan S Flisiak Robert R Knysz Brygida B Lueth Stefan S Zarebska-Michaluk Dorota D Janczewska Ewa E Ferenci Peter P Diago Moises M Zignego Anna Linda AL Safadi Rifaat R Baruch Yaacov Y Abdurakhmanov Dzhamal D Shafran Stephen S Thabut Dominique D Bruck Rafael R Gadano Adrian A Thompson Alexander James AJ Kopit Justin J McPhee Fiona F Michener Tracy T Hughes Eric A EA Yin Philip D PD Noviello Stephanie S
World journal of gastroenterology 20160301 12
<h4>Aim</h4>To evaluate daclatasvir vs telaprevir, each combined with peginterferon alfa-2a/ribavirin (pegIFN/RBV), in treatment-naive hepatitis C virus (HCV) genotype (GT) 1-infected patients.<h4>Methods</h4>In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned (2:1) to daclatasvir vs telaprevir, stratified by IL28B rs12979860 host genotype (CC vs non-CC), cirrhosis status (compensated cirrhosis vs no cirrhosis), and HCV GT1 subtype (GT1a vs GT1b). P ...[more]