Ontology highlight
ABSTRACT:
SUBMITTER: Valind A
PROVIDER: S-EPMC4806331 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Valind Anders A Haikal C C Klasson M E K ME Johansson M C MC Gullander J J Soller M M Baldetorp B B Gisselsson David D
Scientific reports 20160324
Somatic mosaicism, the presence of genetically distinct cells within an organism, has been increasingly associated with human morbidity, ranging from being a cause of rare syndromes to a risk factor for common disorders such as malignancy and cardiovascular disease. Previous studies interrogating the normal prevalence of somatic mosaicism have focused on adults. We here present an estimate of the baseline frequency of somatic mosaic copy number variation (CNV) at the time around birth, by sampli ...[more]