Ontology highlight
ABSTRACT:
SUBMITTER: Han B
PROVIDER: S-EPMC4806384 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cell reports 20151101 5
The mesoderm- and epithelial-mesenchymal transition-associated transcription factor FOXC1 is specifically overexpressed in basal-like breast cancer (BLBC), but its biochemical function is not understood. Here, we demonstrate that FOXC1 controls cancer stem cell (CSC) properties enriched in BLBC cells via activation of Smoothened (SMO)-independent Hedgehog (Hh) signaling. This non-canonical activation of Hh is specifically mediated by Gli2. Furthermore, we show that the N-terminal domain of FOXC1 ...[more]