Gut microbiota composition and relapse risk in pediatric MS: A pilot study.
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ABSTRACT:
SUBMITTER: Tremlett H
PROVIDER: S-EPMC4806409 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Gut microbiota composition and relapse risk in pediatric MS: A pilot study.
Tremlett Helen H Fadrosh Douglas W DW Faruqi Ali A AA Hart Janace J Roalstad Shelly S Graves Jennifer J Lynch Susan S Waubant Emmanuelle E
Journal of the neurological sciences 20160220
We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion (p=0.001 log-rank test), expansion of the Firmicutes (p=0.003), and presence of the Archaea Euryarchaeota (p=0.037). After covariate adj ...[more]
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