Ontology highlight
ABSTRACT:
SUBMITTER: Choi E
PROVIDER: S-EPMC4806642 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Choi Erika E Branch Craig C Cui Min-Hui MH Yazdanbakhsh Karina K Mohandas Narla N Billett Henny H HH Shi Patricia A PA
Blood cells, molecules & diseases 20151221
Gene therapy for sickle cell disease is currently in active trials. Collecting hematopoietic progenitor cells safely and effectively is challenging, however, because granulocyte colony stimulating factor, the drug used most commonly for mobilization, can cause life-threatening vaso-occlusion in patients with sickle cell disease, and bone marrow harvest requires general anesthesia and multiple hip bone punctures. Plerixafor is an inhibitor of the CXCR4 chemokine receptor on hematopoietic progenit ...[more]