Ontology highlight
ABSTRACT:
SUBMITTER: Mitani Y
PROVIDER: S-EPMC4807116 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Mitani Yoshitsugu Y Liu Bin B Rao Pulivarthi H PH Borra Vishnupriya J VJ Zafereo Mark M Weber Randal S RS Kies Merrill M Lozano Guillermina G Futreal P Andrew PA Caulin Carlos C El-Naggar Adel K AK
Clinical cancer research : an official journal of the American Association for Cancer Research 20151202 3
<h4>Purpose</h4>Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy, characterized by t(6;9) translocations and MYB-NFIB gene fusions in approximately 50% of the tumors. The genetic alterations underlying t(6;9)-negative and t(6;9)-positive/MYB-NFIB fusion-negative ACC remain unknown. To uncover the genetic alterations in ACC lacking the canonical translocation and fusion transcript and identify new abnormalities in translocation positive tumors.<h4>Experimental design</h4>We ...[more]