Ontology highlight
ABSTRACT:
SUBMITTER: Zhu H
PROVIDER: S-EPMC4807159 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhu Hongyi H Guo Shangchun S Zhang Yuelei Y Yin Junhui J Yin Wenjing W Tao Shicong S Wang Yang Y Zhang Changqing C
International journal of biological sciences 20160205 4
The pHs of extracellular fluids (ECFs) in normal tissues are commonly maintained at 7.35 to 7.45. The acidification of the ECF is one of the major characteristics of tumour microenvironment. In this study, we report that decreased extracellular pH promotes the transformation of mesenchymal stem cells (MSCs) into cancer-associated fibroblasts (CAFs), termed CAF activation. Furthermore, we demonstrate that GPR68, a proton-sensing G-protein-coupled receptor (GPCR), is required for the pH-dependent ...[more]