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Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum.

ABSTRACT: The traditional view of the structure-function paradigm is that a protein's function is inextricably linked to a well defined, three-dimensional structure, which is determined by the protein's primary amino acid sequence. However, it is now accepted that a number of proteins do not adopt a unique tertiary structure in solution and that some degree of disorder is required for many proteins to perform their prescribed functions. In this review, we highlight how a number of protein functions are facilitated by intrinsic disorder and introduce a new protein structure taxonomy that is based on quantifiable metrics of a protein's disorder.

SUBMITTER: Burger VM

PROVIDER: S-EPMC4807258 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum.

Burger Virginia M VM Nolasco Diego O DO Stultz Collin M CM

The Journal of biological chemistry 20160205 13

The traditional view of the structure-function paradigm is that a protein's function is inextricably linked to a well defined, three-dimensional structure, which is determined by the protein's primary amino acid sequence. However, it is now accepted that a number of proteins do not adopt a unique tertiary structure in solution and that some degree of disorder is required for many proteins to perform their prescribed functions. In this review, we highlight how a number of protein functions are fa ...[more]

PMID: 26851282

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