GDF 15--A Novel Biomarker in the Offing for Heart Failure.

ABSTRACT:

Background

Several diagnostic and prognostic biomarkers are being explored in heart failure. GDF-15 belongs to the transforming growth factor β (TGF-β) cytokine family that is highly up regulated in inflammatory conditions. We undertook this systematic review to summarize the current evidence on the utility of GDF-15 as a biomarker in heart failure.

Design and methods

Multiple electronic databases for studies that reported the association between GDF- 15 and heart failure were searched using different electronic databases such as MEDLINE, Science Direct, Springer Link, Scopus, Cochrane Reviews, and Google Scholar using pre-defined inclusion- exclusion criteria.

Results

Twenty one original studies were identified that included data from 20,920 study participants. GDF 1

SUBMITTER: George M 

PROVIDER: S-EPMC4807717 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature