Ontology highlight
ABSTRACT:
SUBMITTER: Chen JY
PROVIDER: S-EPMC4808012 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Chen Jhen-Yu JY Chen Yun-Ju YJ Yen Chia-Jui CJ Chen Wen-Shu WS Huang Wei-Chien WC
Oncotarget 20160101 1
Poor prognosis of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) involves HBV X protein (HBx)-induced tumor progression. HBx also contributes to chemo-resistance via inducing the expressions of anti-apoptosis and multiple drug resistance genes. However, the impact of HBx expression on the therapeutic efficacy of various receptor tyrosine kinase inhibitors remains unknown. In this study, our data showed that HBx overexpression did not alter the cellular sensitivity of HCC cell ...[more]