Molecular pathway activation features linked with transition from normal skin to primary and metastatic melanomas in human.

ABSTRACT: Melanoma is the most aggressive and dangerous type of skin cancer, but its molecular mechanisms remain largely unclear. For transcriptomic data of 478 primary and metastatic melanoma, nevi and normal skin samples, we performed high-throughput analysis of intracellular molecular networks including 592 signaling and metabolic pathways. We showed that at the molecular pathway level, the formation of nevi largely resembles transition from normal skin to primary melanoma. Using a combination of bioinformatic machine learning algorithms, we identified 44 characteristic signaling and metabolic pathways connected with the formation of nevi, development of primary melanoma, and its metastases. We created a model describing formation and progression of melanoma at the level of molecular pathway acti

SUBMITTER: Shepelin D 

PROVIDER: S-EPMC4808024 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature