GDF15 promotes EMT and metastasis in colorectal cancer.
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ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC4808038 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
GDF15 promotes EMT and metastasis in colorectal cancer.
Li Chen C Wang Jingyu J Kong Jianlu J Tang Jinlong J Wu Yihua Y Xu Enping E Zhang Honghe H Lai Maode M
Oncotarget 20160101 1
Metastasis is the major cause of cancer deaths, and the epithelial-mesenchymal transition (EMT) has been considered to be a fundamental event in cancer metastasis. However, the role of growth differentiation factor 15 (GDF15) in colorectal cancer (CRC) metastasis and EMT remains poorly understood. Here, we showed that GDF15 promoted CRC cell metastasis both in vitro and in vivo. In addition, the EMT process was enhanced by GDF15 through binding to TGF-β receptor to activate Smad2 and Smad3 pathw ...[more]
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