Ontology highlight
ABSTRACT:
SUBMITTER: Popella P
PROVIDER: S-EPMC4808217 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Popella Peter P Krauss Sophia S Ebner Patrick P Nega Mulugeta M Deibert Julia J Götz Friedrich F
Antimicrobial agents and chemotherapy 20160325 4
In bacteria, extracellular signals are transduced into the cell predominantly by two-component systems (TCSs) comprising a regulatory unit triggered by a specific signal. Some of the TCSs control executing units such as ABC transporters involved in antibiotic resistance. For instance, inStaphylococcus aureus, activation of BraSR leads to the upregulation ofvraDEexpression that encodes an ABC transporter playing a role in bacitracin and nisin resistance. In this study, we show that the small stap ...[more]