Ontology highlight
ABSTRACT:
SUBMITTER: Kiss AM
PROVIDER: S-EPMC480876 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Kiss Arnold M AM Jády Beáta E BE Bertrand Edouard E Kiss Tamás T
Molecular and cellular biology 20040701 13
Pseudouridine, the most abundant modified nucleoside in RNA, is synthesized by posttranscriptional isomerization of uridines. In eukaryotic RNAs, site-specific synthesis of pseudouridines is directed primarily by box H/ACA guide RNAs. In this study, we have identified 61 novel putative pseudouridylation guide RNAs by construction and characterization of a cDNA library of human box H/ACA RNAs. The majority of the new box H/ACA RNAs are predicted to direct pseudouridine synthesis in rRNAs and spli ...[more]