Ontology highlight
ABSTRACT:
SUBMITTER: Waldhuber A
PROVIDER: S-EPMC4810146 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Waldhuber Anna A Snyder Greg A GA Römmler Franziska F Cirl Christine C Müller Tina T Xiao Tsan Sam TS Svanborg Catharina C Miethke Thomas T
Pathogens (Basel, Switzerland) 20160229 1
The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR- ...[more]