Ontology highlight
ABSTRACT:
SUBMITTER: Farrow AL
PROVIDER: S-EPMC4810268 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Farrow Anitra L AL Peng Binghao J BJ Gu Linlin L Krendelchtchikov Alexandre A Matthews Qiana L QL
Viruses 20160310 3
Due to the increasing amount of people afflicted worldwide with Chagas disease and an increasing prevalence in the United States, there is a greater need to develop a safe and effective vaccine for this neglected disease. Adenovirus serotype 5 (Ad5) is the most common adenovirus vector used for gene therapy and vaccine approaches, but its efficacy is limited by preexisting vector immunity in humans resulting from natural infections. Therefore, we have employed rare serotype adenovirus 48 (Ad48) ...[more]