Ontology highlight
ABSTRACT:
SUBMITTER: Melchionda M
PROVIDER: S-EPMC4810305 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Melchionda Manuela M Pittman Jon K JK Mayor Roberto R Patel Sandip S
The Journal of cell biology 20160321 7
Increasing evidence implicates Ca(2+) in the control of cell migration. However, the underlying mechanisms are incompletely understood. Acidic Ca(2+) stores are fast emerging as signaling centers. But how Ca(2+) is taken up by these organelles in metazoans and the physiological relevance for migration is unclear. Here, we identify a vertebrate Ca(2+)/H(+)exchanger (CAX) as part of a widespread family of homologues in animals. CAX is expressed in neural crest cells and required for their migratio ...[more]